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Thursday, October 22, 2020 | History

3 edition of Molecular genetics of colorectal neoplasia found in the catalog.

Molecular genetics of colorectal neoplasia

Molecular genetics of colorectal neoplasia

a primer for the clinician

  • 243 Want to read
  • 17 Currently reading

Published by Kluwer Academic Publishers in Boston .
Written in English

    Subjects:
  • Colon (Anatomy) -- Cancer -- Genetic aspects.,
  • Rectum -- Cancer -- Genetic aspects.,
  • Colon (Anatomy) -- Cancer -- Molecular aspects.,
  • Rectum -- Cancer -- Molecular aspects.,
  • Colorectal Neoplasms -- genetics.,
  • Molecular Biology -- methods.

  • Edition Notes

    Statement[edited by] James Church and Graham Casey.
    SeriesDevelopments in oncology -- v. 82
    ContributionsChurch, James M., Casey, Graham., Church, James M.
    Classifications
    LC ClassificationsRC280.C6 C48 2004
    The Physical Object
    Paginationxviii, 174 p. :
    Number of Pages174
    ID Numbers
    Open LibraryOL19290603M
    ISBN 101402076118
    LC Control Number2003061201


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Molecular genetics of colorectal neoplasia Download PDF EPUB FB2

Molecular Genetics of Colorectal Neoplasia A Primer for the Clinician provides the latest information on the genetics of colorectal cancer within a context of basic genetics, describing the subject in understandable language and making it clinically relevant.

In this way, clinicians can become familiar with genetic terms and techniques related to colorectal neoplasia, providing a background upon which to. Molecular Genetics of Colorectal Neoplasia A Primer for the Clinician provides the latest information on the genetics of colorectal cancer within a context of basic genetics, describing the subject in understandable language and making it clinically relevant.

In this way, clinicians can become familiar with genetic terms and techniques related to colorectal neoplasia, providing a background upon which to Brand: Springer US. Church J., Casey G. () Molecular Genetics of Colorectal Neoplasia. In: Molecular Genetics of Colorectal Neoplasia.

Developments in Oncology, vol Springer, Boston, MA. DOI ; Publisher Name Springer, Boston, MA; Print ISBN ; Online ISBN ; eBook Packages Springer Book ArchiveAuthor: James Church, Graham Casey. Revised edition of: Molecular genetics of colorectal neoplasia / James M. Church, Bryan R.G.

Williams, Graham Casey. c Description: xviii, pages: illustrations ; 24 cm. Contents: Ch. An introduction to genetics --Ch. Changes in gene function --Ch. Molecular genetics methods simplified --Ch. Genes and cell homeostasis --Ch. The Stage Is Set The rapid advances in the molecular genetics of colorectal neoplasia were facilitated by the characteris tics of the disease itself.

First, colorectal cancer is com mon in Western countries, representing the second most frequent cause of Cited by:   Introduction. Colorectal neoplasia results from an accumulation of genetic abnormalities in the nuclei of clones of colonocytes that allow the cells to escape the normal controls on cellular growth, death, and differentiation.

John K. Cowell. Gulf Professional Publishing, - Medical - pages. 0 Reviews. Since the first volume was published, there has been significant success in isolating genes responsible for. Abstract. Colorectal cancer is a common but heterogeneous disease, which arises through the accumulation of genetic mutations.

Knowledge of the molecular basis of colorectal cancer has advanced at a rapid pace in recent years, reflecting progress made in the field of genomic medicine. Targeted therapies have come into mainstream use, and the exciting prospect of treatment. Recommend this book. Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients.

An update on the genetics of colorectal cancer. Human Molecular Genetics, 13, – Kinzler, K. molecular genetics of colorectal neoplasia undoubt- edly occupies the smallest portion of the last half cen- tury that the Essays cover, because the entire body of knowledge has accumulated in less than a decade.

Nonetheless, clinical application of this knowledge to impact on the incidence and mortality from colorectal. A variety of genetic and molecular alterations underlie the development and progression of colorectal neoplasia (CRN).

Most of these cancers arise sporadically due to multiple somatic mutations and genetic instability. Genetic instability includes chromosomal instability (CIN) and microsatellite instability (MSI), which is observed in most.

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Colorectal cancer is a significant cause of morbidity and mortality in Western populations. This cancer develops as a result of the pathologic transformation of normal colonic epithelium to an adenomatous polyp and ultimately an invasive cancer.

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In addition to the adenoma to carcinoma sequence, colorectal carcinogenesis can occur via the serrated pathway. Studies have focused on clarification of categories and molecular features of serrated polyps, as well as endoscopic detection and risk assessment.

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